PO-01-072 INTER-PROCEDURAL REPRODUCIBILITY OF ELECTROGRAPHIC FLOW MAPPING BETWEEN PROCEDURES SEPARATED BY 3 MONTHS OR LONGER

Over the last decade, various algorithms for localizing extra-pulmonary vein (PV) AF drivers/sources (focal or rotational activity) have been studied. Validating these mapping systems is confounded by lack of ground truth, typically manifesting as poor map reproducibility. Short optical studies, it remains difficult to prove that identified drivers are true drivers, so other criteria needed buttress specificity sources. Electrographic flow (EGF) uses a novel technique create full, near real-time spatiotemporal visualizations atrial electrical wavefront propagation identify putative fibrillation (AF) To evaluate whether source activity EGF reproducible over procedures separated ≥ 3 months. As part FLOW-AF trial (NCT04473963), 18 pts underwent de novo balloon-based PVI and post-PVI with 64-pole basket catheter. At ∼3 months, remap procedure included check + mapping. Confirmation ≥20 min wait confirm isolation was required in both procedures. One pt excluded position not stored such anatomic location could be verified, 5 were since non-inducible at remapping. Of 12 who fully mapped re-mapped (at 99.7 ± 20.9 days post-PVI), after PVI, sources > 26% (the threshold qualify legitimate) detected (10 RA, 8 LA, 7 atria). The revealed 16 (89.0%) same initial procedure; remaining 2 SVC again seen on remap, but different aspect SVC. patient did any procedure, found an RA PVs re-isolated during procedure. produces results from one next, if clinically relevant first ablated, detectable remapping performed 3-mo PVI. This inter-procedural reproducibility may enable longitudinal follow-up individual patients’ pathophysiology.